Intrauterine Insemination: IUI

Intrauterine Insemination: IUI

Intrauterine insemination (IUI) is a fertility treatment that involves placing sperm inside a woman’s uterus to facilitate fertilization. The goal of IUI is to increase the number of sperm that reach the fallopian tubes and subsequently increase the chance of fertilization. IUI provides the sperm an advantage by giving it a head start, but still requires a sperm to reach and fertilize the egg on its own. It is a less invasive and less expensive option compared to in vitro fertilization.

When is IUI used?

The most common reasons for IUI are a low sperm count or decreased sperm mobility. However, IUI may be selected as a fertility treatment for any of the following conditions as well:

  • Unexplained infertility
  • A hostile cervical condition, including cervical mucus problems
  • Cervical scar tissue from past procedures which may hinder the sperms’ ability to enter the uterus
  • Ejaculation dysfunction

IUI is not recommended for the following patients:

  • Women who have severe disease of the fallopian tubes
  • Women with a history of pelvic infections
  • Women with moderate to severe endometriosis
IUI Intrauterine Insemination

How does IUI work?

Before intrauterine insemination, ovulation stimulating medications may be used, in which case careful monitoring will be necessary to determine when the eggs are mature. The IUI procedure will then be performed around the time of ovulation, typically about 24-36 hours after the surge in LH hormone that indicates ovulation will occur soon.

A semen sample will be washed by the lab to separate the semen from the seminal fluid. A catheter will then be used to insert the sperm directly into the uterus. This process maximizes the number of sperm cells that are placed in the uterus, thus increasing the possibility of conception. The IUI procedure takes only a few minutes and involves minimal discomfort. The next step is to watch for signs and symptoms of pregnancy.

What are the risks of IUI?

The chances of becoming pregnant with multiples is increased if you take fertility medication when having IUI. There is also a small risk of infection after IUI.

How successful is IUI?

The success of IUI depends on several factors. If a couple has the IUI procedure performed each month, success rates may reach as high as 20% per cycle depending on variables such as female age, the reason for infertility, and whether fertility drugs were used, among other variables. While IUI is a less invasive and less expensive option, pregnancy rates from IUI are lower than those from IVF. If you think you may be interested in IUI, talk with your doctor to discuss your options.

Last Updated: 09/2014


Compiled using information from the following sources:

American Society for Reproductive Medicine. (2012). Intrauterine insemination (IU). Retrieved from https://www.asrm.org/FACTSHEET_Intrauterine_Insemination_IUI/
RESOLVE: The National Infertility Association. (n.d.). IUI. Retrieved from http://www.resolve.org/family-building-options/iui/
Smith, D. (2013). Intrauterine insemination: Will it help me conceive? Retrieved from http://www.resolve.org/family-building-options/iui/intrauterine-insemination-will-it-help-me-conceive.html