I have had 2 miscarriages in the last year, and my doctor did a blood work up recently. Everything was negative/normal, except for 2 mutations to the MTHFR gene, which can affect folic acid synthesis. My doctor said that with these defects, the body doesn't break down and process folic acid properly into a usable form (among many other potential cardiovascular effects not related to pregnancy), therefore the levels aren't high enough, leading to neural tube and other midline defects. I have a lot of questions for my doctor, but I'm just wondering if anyone else has this or any experience with it? I have a perfectly healthy 4 year old, but had a miscarriage last summer, then a blighted ovum this spring, and a possible chemical pregnancy prior to those. I am on a prenatal that has Quatrefolic acid in it now, but does anyone have any information on this? Thank you!